Bloodline
Will Lofty and Dom’s marriage survive under the pressure of Isaac’s presence at Holby, and is Sacha’s relationship with Patricia over before it’s even begun?
More from Series 21
Episode 1
Everything Old Is New Again
Jac, Ric and Sacha face off against old rivals while pitching for a million-pound prize fund. But as the competition threatens to divide the group, should they be more worried about their friends than their enemies? Serena's new year is once again marked by tragedy when a loved one is brought in for emergency surgery. Dare Serena put her personal feelings aside and perform the operation to prevent history repeating itself?
Episode 2
China Crisis
A surprise blast from the distant past returns to run a Young Adult Unit alongside top consultant Ange Godard. He successfully puts everyone on tenterhooks with his notorious barbs and quips, until things take a surprising turn, much to everyone's surprise. Nicky competes with Cameron for the junior doctor lead position only to realise that high accolades aren't everything when it to come to surgery. Serena steps in to protect her ward when an old face from the past turns up and offends them. Serena fails to see the funny side and takes control.
Episode 3
The Burden of Proof
Ange finally allows Dominic the chance to work on her new unit, after much persistence, but she isn't sure whether he has the chops to be a great doctor. When Dominic is economical with the truth, Ange has to confront him and then feels that he's not trustworthy. Nicky and Cameron find common ground when they have to work alongside an unforgiving Jac. Struggling to prove that he's worthy, Cameron goes all out to impress her. When things go wrong, will Cameron be forced to confront his own mistakes? Ric's former wife Lola returns to Holby to work alongside her former flame on AAU. Serena and Zav are highly amused by the tension between them, but Ric soon realises that he actually has residual feelings for his ex. But are they reciprocated?
Episode 4
A Daring Adventure or Nothing at All
Frieda is happy her life is on an even keel, but her contentment is shattered when her ex-boyfriend Roman unexpectedly reappears. Can a wary Frieda open her heart and dare to imagine a future she had thought was gone for good? With their relationship going well, Xavier is keen to step up and ease the burdens weighing on a stressed Donna. But all does not entirely go to plan when Zav embarks on some impromptu parenting of Mia. Ange feels the pressure as she works to sell her vision for her Young Adult Unit while treating a difficult and vulnerable patient. But striving to be all things to all people, Ange fails to get to grips with the behaviour of a returning colleague who might really need help.
Episode 5
Mad as Hell
When Holby is overwhelmed by a winter crisis, Ric goes above and beyond to treat his patients. But as the pressure reaches fever pitch, can he continue to accept Holby surviving on nothing more than good will and the occasional miracle? To Jac and Fletch's concern, a grief-stricken Frieda immerses herself completely in work, but when she's challenged by a patient's confrontational father, and with her emotions running high, Frieda embarks on a fight she has to win. When Ange has her work cut out on YAU thanks to an obstinate teenager, it's down to Essie to persuade an unwilling Ange to enlist help from a source who's a bit too close to home.
Episode 6
Force Majeure
When a family secret is exposed, the dispute causes a young patient to delay vital surgery, but fearing the consequences of such a decision, a concerned Ange must find a way to make her reconsider. Keen to highlight the constant pressures Holby faces on a daily basis, Ric enlists the help of an influential acquaintance. But when an innocent patient is caught up in his personal crusade will Ric do the right thing? When the opportunity to attend an overseas conference arises, Nicky and Cameron must battle it out, but with Nicky running on empty does she have the strength to come out on top?
